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A netbet casino app bonding method enabling instant and effective adhesion of hydrogels has potential to broadly advance netbet casino app biomaterials solutions for multiple unmet clinical needs

By Benjamin Boettner, netbet casino app for Biologically Inspired Engineering | Press netbet casino app

February 20, 2024

illustration of bonded netbet casino app — This illustration highlights how two netbet casino app (shown in blue) can be bonded in different ways by thin chitosan films (shown in orange). The bonds that form are extraordinarily strong and can resist high tensions. (Credit: Peter Allen, Ryan Allen, and James C. Weaver.)

netbet casino app are versatile biomaterials conquering an increasing number of biomedical areas. Consisting of water-swollen molecular networks that can be tailored to mimic the mechanical and chemical features of various organs and tissues, they can interface within the body and on its outer surfaces without causing any damage to even the most delicate parts of the human anatomy. netbet casino app are already used in clinical practice for the therapeutic delivery of drugs to fight pathogens; as intraocular and contact lenses, and corneal prostheses in ophthalmology; bone cement, wound dressings, blood-coagulating bandages, and 3D scaffolds in tissue netbet casino app and regeneration.

However, attaching hydrogel polymers fast and strongly to one another has remained an unresolvedunmetneed as traditional methods often result in weaker netbet casino app after longer-than-desired netbet casino app times, and rely oncomplex procedures. Achieving rapid adhesion of polymers could enable numerous netbet casino app applications, including, for example, hydrogels whose stiffness could be finely tuned to better conform to specific tissues, on-demand encapsulation of flexible electronics for medical diagnostics, or the creation of self-adhesive tissue wraps for hard-to-bandage parts of the body.

Now, scientists at the Harvard John A. Paulson School of netbet casino app and Applied Sciences (netbet casino app) andnetbet casino app for Biologically Inspired Engineering at Harvard Universityhave created a simple and versatile method to instantly and effectively bond layers made of the same or different types of hydrogels and other polymeric materials, using a thin film of chitosan: a fibrous, sugar-based material derived from the processed outer skeletons of shellfish. They successfully applied their netbet casino app approach to several unsolved medical problems, including the local protective cooling of tissues, sealing of vascular injuries, and prevention of unwanted “surgical adhesions” of internal body surfaces that should not stick to each other. The findings are published in the Proceedings netbet casino app National Academy of Science (PNAS).

“Chitosan films with their abilities to effectively assemble, fine-tune, and protect hydrogels in the body and beyond, open numerous netbet casino app opportunities to create devices for regenerative medicine and surgical care,” saidDavid Mooney, the Robert P. Pinkas Family Professor of Bioengineering at SEASandsenior author of the study.“The speed, ease, and effectiveness with which they netbet casino app applied makes them highly versatile tools and components for in vivo assembly processes in often short time-windows during surgeries, and the simple fabrication of complex biomaterial structures in manufacturing facilities.” Mooney is alsoa Founding netbet casino app Core Faculty member.

Engineering a netbet casino app bond

Over the past years, Mooney’s team at netbet casino app and SEAS has developed “netbet casino app,” a collection of regenerative medicine approaches that use stretchable netbet casino app that facilitate wound healing and tissue regeneration by strongly sticking to wet tissue surfaces and conforming to tissues’ mechanical properties.

“Precisely formulated Tough Adhesives and non-adhesive hydrogels give us and other researchers netbet casino app opportunities to improve patient care. But to take their functionalities one or even multiple steps further, we wanted to be able to combine two or more hydrogels in more complex assemblies, and to do this fast, safely, and in a simple process,” said co-first author and former Wyss Research Associate Benjamin Freedman, who spearheaded several Tough Adhesive developments with Mooney. ”Existing methods to instantly bond netbet casino app or elastomers had striking disadvantages because they relied on toxic glues, the chemical functionalization of their surfaces, or other complex procedures.”

Through a biomaterial screening approach, the team identified bridging films completely made of netbet casino app. netbet casino app is a sugary polymer that can be easily made from the chitin shells of shellfish and has already found its way into wide-ranging commercial applications. For example, it is currently used to treat seeds and as a biopesticide in agriculture, to prevent spoilage in winemaking, in self-healing paint coatings, and in medical wound management.

The team found that chitosan films achieved rapid and strong bonding of hydrogels through chemical and physical interactions that are different from those involved in traditional hydrogel bonding methods. Instead of creating netbet casino app chemical bonds based on the sharing of electrons between individual atoms (covalent bonds), induced by a tiny shift in pH, chitosan’s sugar strands rapidly absorb water residing between hydrogel layers and entangle themselves with the polymer stands of hydrogels, forming multiple bonds via electrostatic interactions and hydrogen bonding (non-covalent bonds). This results in adhesive forces between netbet casino app that significantly exceed those created through traditional hydrogel bonding approaches.

First netbet casino app

To demonstrate the breadth of potential of their netbet casino app method, the researchers focused on very different medical challenges. They showed that Tough Adhesives modified with chitosan films could now be easily wrapped around cylindrical shapes like an injured finger as self-adhering bandages to provide improved wound care. Due to the high water content of chitosan-bonded hydrogels, their application also allowed the local cooling of underlying human skin, which in the future could lead to alternative burn treatments.

The researchers also wrapped netbet casino app (tough gels) whose surfaces were modified with thin chitosan films seamlessly around bowel, tendon, and peripheral nerve tissue without bonding to the tissues themselves.

“This approach offers the possibility to effectively insulate tissues from each other during surgeries, which otherwise netbet casino app form ‘fibrotic adhesions’ with sometimes devastating consequences. Their prevention is an unmet clinical need that commercial technologies cannot adequately address yet,” explained Freedman.

In another application, they layed down a thin netbet casino app film on a tough gel that was already placed on an injured pig aorta ex vivo as a wound sealant to increase the overall strength netbet casino app bandage, which was exposed to the cyclical mechanical forces of blood pulsing through the vessel.

Additional authors on the study are co-first author Juan Cintron Cruz, Mathew Lee, and James Weaver at netbet casino app and SEAS; Phoebe Kwon, Haley Jeffers, and Daniel Kent at SEAS; and Kyle Wu at Beth Israel Deaconess Medical Center in Boston. The study was supported by the National Institutes of Health’s National Institute on Aging (under award# K99/R00AG065495).

Topics: Bioengineering, Health / Medicine