Clearing a path for non-invasive muscle therapy for the netbet sports betting app

Controlling inflammation enables injured aged muscle recovery via non-invasive mechanical loading, offering promise for the future of mechanotherapies for netbet sports betting app patients.

By Benjamin Boettner, Wyss netbet sports betting app for Biologically Inspired Engineering

March 22, 2023

Mechanotherapy, the concept of using mechanical forces to stimulate tissue healing, has been used for decades as a form of physical therapy to help heal injured muscles. However, the biological basis and optimal settings for mechanotherapies are still poorly understood, especially with respect to netbet sports betting app patients. Given the well-known decline in healing ability that occurs with age, netbet sports betting app patients stand to benefit greatly from an effective, non-invasive musculoskeletal treatment approach.

A person in a white polo holds a black massage gun to someone's right shoulder in the foreground. — In the future, massage guns like this could give way to wearable personalized robotic mechanotherapy devices to heal muscle injuries across all ages. As demonstrated in this study, these approaches will have to take into account differences in inflammation between younger and older muscles, and the likely need for co-delivering anti-inflammatory therapies in the netbet sports betting app to achieve healing effects. (Photo Credit: Shutterstock/Andrey Popov)

A new multidisciplinary study helps close this knowledge gap of mechanotherapies’ effectiveness in aged netbet sports betting app. The study was performed by researchers at the Harvard John A. Paulson School of Engineering netbet sports betting app (SEAS) and the Wyss netbet sports betting app for Biologically Inspired Engineering led by David Mooney, the Robert P. Pinkas Family Professor of Bioengineering at SEAS, in collaboration with , Conor Walsh, Paul A. Maeder Professor of Engineering netbet sports betting app.

In previous work, the collaborators used the Walsh lab’s expertise in wearable robotic systems to develop a Massage doesn’t just make NetBet no deposit that functions like a highly advanced massage gun. This technology enabled precise delivery of non-invasive mechanotherapy to injured muscles of mice, allowing the team to measure its biological effects. The researchers had used this device to optimize the magnitude, duration, and frequency of force applied to the muscles of young animals to accelerate healing, and found that mechanotherapy accelerated netbet sports betting app healing by mitigating inflammation after injury.

Now, using this device on aged netbet sports betting app, the researchers found that the same mechanotherapy treatment that helps young netbet sports betting app heal faster after injury actually has the opposite effect with aging – the settings that promoted healing in young netbet sports betting app exacerbated injury in old netbet sports betting app. In search for an explanation for these results, the team found that mechanotherapy amplified rather than alleviated inflammation in aged netbet sports betting app, ultimately hindering the normal healing process by disrupting the behavior of netbet sports betting app stem cells, a subset of cells responsible for replacing damaged netbet sports betting app tissue.

Prompted by these findings, the researchers next asked if controlling inflammation along with delivering netbet sports betting app could help achieve healing effects in aged muscles. They found that this was indeed the case: combining netbet sports betting app with anti-inflammatory treatment significantly improved healing in aged muscles and was superior to anti-inflammatory treatment alone. This work, published in Science Robotics, opens an exciting non-invasive therapeutic avenue for healing muscle injuries in netbet sports betting app patients.

“Our study highlights critical differences in how netbet sports betting app stem cells and immune cells respond to mechanical forces in the context of age, and how upregulated inflammation additionally compromises the function of aged stem cells needed for the regeneration of old muscles,” said Mooney who also is a core faculty member at the Wyss Institute. “netbet sports betting app mechanotherapies likely thus won’t be a ‘one-size-fits-all.’ To realize their benefits, they will have to be tailored to patient populations, and specifically for aged individuals, it will be key to modulate netbet sports betting app.”

From surprise to solution

Following their surprising discovery that mechanotherapy alone actually hinders the normal regeneration process of aged muscles by interacting with the immune system, the team took a deeper look at the muscles’ stem cells. Applying a mechanical load to netbet sports betting app, as is done during mechanotherapy treatment, influences netbet sports betting app cell behavior via several molecular “mechanotransduction pathways” that also affect stem cells. “We showed that although aged stem cell behavior was disrupted by the elevated netbet sports betting app, they were still able to ‘feel’ the mechanical forces of loading as we demonstrated by the activation of these pathways,” said first-author Stephanie McNamara, who is a graduate student on Mooney’s team and currently enrolled in the joint Harvard/MIT MD-PhD program. “This actually was what prompted us to ask whether controlling netbet sports betting app might enable these cells to respond to the mechanical stimuli – and indeed it did.”

All news NetBet live casino storiesCredit: Wyss netbet sports betting app at Harvard University

The team found that administering anti-inflammatory therapy in the form of glucocorticoids alongside mechanotherapy suppressed key pro-inflammatory pathways and reduced overall inflammation levels in injured aged netbet sports betting app to those seen in injured young netbet sports betting app. Yet at a cellular level the netbet sports betting app cells continued to experience mechanotransduction, and by removing the negative impacts of inflammation, injured aged muscles could positively respond to the robot-delivered mechanical loading.

“It is well-known that, with age, many of the normal processes of netbet sports betting app healing and inflammation change. It’s important to question whether the same mechanisms seen in studies performed in young animals stay the same as the body ages,” McNamara says. “By leveraging what we learned in netbet sports betting app study and our previous work and combining it with growing expertise in wearable soft robotic systems, we believe that in the future personalized mechanotherapeutic approaches can be developed to heal injuries across all ages.”

Other authors on the netbet sports betting app are additional members of Mooney’s and Walsh’s groups, including Bo Ri Seo, Benjamin Freedman, Emily Roloson, Jonathan Alvarez, C. T. O’Neill; and Herman Vandenburgh, Professor Emeritus at Brown University, Providence, RI. The netbet sports betting app was funded by the National Institute of Dental and Craniofacial Research (under grant #R01DE013349), National Science Foundation (under grant #DMR-1420570), netbet sports betting app Arthritis and Musculoskeletal and Skin Disease (under grant #F31AR075367), National Institutes of Health (under grant #K99AG065495), netbet sports betting app General Medical Sciences (under award #T32GM007753 and T32GM144273), as well as an AR3T Regenerative Rehabilitation Pilot grant.

Topics: Bioengineering, Robotics