Shape-shifting immune cells offer new insights into cancer immunotherapy netbet sports betting

Research sheds light on long-standing question

By Leah Burrows | Press contact

November 14, 2023

netbet sports betting (red) inside a tumor spheroid — netbet sports betting (red) infiltrating a tumor spheroid (Credit: The Mitragotri Laboratory for Drug Delivery/Harvard SEAS)

netbet sports betting, a type of white blood cell that can destroy invading pathogens, have an innate ability to infiltrate tumor cells, making them a potentially important tool in treatments that use transplanted cells to fight disease, known as cell therapy. In the lab, netbet sports betting show a lot of promise in treating cancer but so far, clinical trials have been a disappointment and biologists are trying to figure out why.

But what if it’s not a biological problem?

In a recent paper, researchers from the netbet sports betting John A. Paulson School of Engineering and Applied Sciences (SEAS) approached the failure of netbet sports betting in clinical trials from an engineering perspective.

The research team, led by Samir netbet sports betting, the Hiller Professor of Bioengineering and Hansjorg Wyss Professor of Biologically Inspired Engineering at SEAS, looked at the physical barriers that might be preventing netbet sports betting from reaching their target in the first place.

By combining microscopy with machine learning, the team found that a specific phenotype of macrophage was better at traveling to the netbet sports betting than others — and it’s not the one that researchers commonly use in the clinic for cancer therapies.

The research was published Applied Physics Reviews.

“Our engineering approach led us to question whether the poor therapeutic outcome of netbet sports betting in cell therapies can in part originate from their inability to get into the tumor in the first place,” said Mitragotri. “And indeed, our results show that different phenotypes exhibit different penetration into the tumor. This provides an interesting physics-based hypothesis for the poor clinical outcome of previously reported macrophage therapies and provides a counter- and complimentary hypothesis to the classical biology-based paradigm.”

There are multiple types of netbet sports betting, simplified as M0, M1, and M2. Of the three, M1 netbet sports betting have the best tumor-fighting capacities and therefore have been used the most for cell therapies. But they have yielded disappointing results in clinical trials.

Mitragotri and his team looked at how each of the three different phenotypes could move through a complex hydrogel and into a netbet sports betting in a petri dish.

“We basically wanted to measure how well the transport mechanics and GPS of these different netbet sports betting worked in a complex environment,” said Kolade Adebowale, a postdoctoral fellow at SEAS and first author of the paper. “We found that the M1 phenotype, anti-tumor microphage, seem to have trouble finding their targets, almost like their GPS wasn’t working. But the M0 phenotype seemed to have a really good map.”

The big question is why.

It’s well known that netbet sports betting exist in various shapes and some phenotypes are really good at changing their shape. Adebowale and the team found a correlation between shape-shifting abilities and transport efficiency — meaning the better the macrophage was at shape shifting, the better able they were to get to the tumor.

And, as it turned out, M1 netbet sports betting are the worst of the three when it comes to shapeshifting.

“Our study demonstrates that the reduced transport of M1 netbet sports betting compared to M0 netbet sports betting is correlated with their reduced ability to undergo shape transformations,” said Adebowale. “We hope that these findings shed new light on the biophysics of macrophage migration and delivery of macrophage cell therapies.”

“There is tremendous potential in utilizing netbet sports betting to mediate anti-tumor immune responses in human tumors and clinical trials are ongoing to treat patients with netbet sports betting,” said Jennifer Guerriero, Assistant Professor at Harvard Medical School, lead investigator of Brigham and Women’s Hospital Breast Oncology Program and co-author of the study. “We learned in this study that, surprisingly, netbet sports betting that resemble an M0 phenotype weremost efficient at getting to netbet sports betting target. These data will have an immediate impact on clinical trials are likely to transform the next generation of macrophage-mediated therapies.”

The research was supported by the National Science Foundation under Award No. 2138064.

Topics: Bioengineering, Health / Medicine